ssun(at)cimrbj.ac.cn
扫码了解更多
扫码了解更多
孙少聪实验室长期致力于肿瘤免疫、自身免疫和炎症反应的研究，重点关注T细胞的功能及其调控机制，包括T细胞耐受、活化、效应功能、耗竭以及肿瘤微环境对T细胞功能的影响。实验室坚持基础研究与临床应用相结合的研究理念，致力于为免疫治疗的发展提供创新思路。主要研究方向包括：1. 探究TNFR-NIK轴调控T细胞功能的分子机制，并开展相关药物靶点的研发；2. 利用体内全基因组CRISPR/Cas9筛选结合基因敲除小鼠模型，鉴定T细胞抗癌功能的新调节因子及癌症免疫治疗新靶点；3. 应用单细胞多组学与生物信息学手段，解析疾病状态下T细胞亚群的动态演变；4. 借助小鼠模型，开发增强CAR-T细胞疗法抗肿瘤效果的新靶点与联合治疗策略。
Zhu L, Zhou X, Kim J, Gu M, Xie X, Li Y, Ko CJ, Gao T, Cheng X, Sun SC. Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion and responses in chronic infection and cancer. Nature Cell Biology, 2022, 24: 1165-1176. DOI: 10.1038/s41556-022-00942-8
Gu M*, Zhou X*, Sohn JH, Zhu L, Jie Z, Yang JY, Zheng X, Xie X, Yang J, Shi Y, Brightbill HD, Kim JB, Wang J, Cheng X, Sun SC. NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity. Nature Immunology, 2021, 22: 193-204. DOI: 10.1038/s41590-020-00829-6
Zhu L, Li Y, Xie X, Zhou X, Gu M, Jie Z, Ko CJ, Gao T, Hernandez BE, Cheng X, Sun SC. TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis. Nature Cell Biology, 2019, 21: 1604-1614. DOI: 10.1038/s41467-018-05097-5
Zhou X, Yu J, Cheng X, Zhao B, Manyam GC, Zhang L, Schluns K, Li P, Wang J, Sun SC. The deubiquitinase Otub1 controls the activation of CD8(+) T cells and NK cells by regulating IL-15-mediated priming. Nature Immunology, 2019, 20: 879-889. DOI: 10.1038/s41590-019-0405-2
Jie Z, Yang JY, Gu M, Wang H, Xie X, Li Y, Liu T, Zhu L, Shi J, Zhang L, Zhou X, Joo D, Brightbill HD, Cong Y, Lin D, Cheng X, and Sun SC. NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis. Nature Immunology, 2018, 19: 1224-1235. DOI: 10.1038/s41590-018-0206-z.
Jin J, Xie X, Xiao Y, Hu H, Zou Q, Cheng X, Sun SC. Epigenetic regulation of the expression of Il12 and Il23 and autoimmune inflammation by the deubiquitinase Trabid. Nature Immunology, 2016, 17: 259-268. DOI: 10.1038/ni.3347
Nakaya M, Xiao Y, Zhou X, Chang JH, Chang M, Cheng X, Blonska M, Lin X, Sun SC. Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation. Immunity, 2014, 40: 692-705. DOI: 10.1016/j.immuni.2014.04.007
Xiao Y, Jin J, Chang M, Chang JH, Hu H, Zhou X, Brittain GC, Stansberg C, Torkildsen Ø, Wang X, Brink R, Cheng X, Sun SC. Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation. Nature Medicine, 2013, 19: 595-602. DOI: 10.1038/nm.3111
Hu H, Brittain GC, Chang JH, Puebla-Osorio N, Jin J, Zal A, Xiao Y, Cheng X, Chang M, Fu YX, Zal T, Zhu C, Sun SC. OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3. Nature, 2013, 494: 371-374. DOI: 10.1038/nature11831
北京市丰台区右安门外西头条10号
010-86738999
cimr@cimrbj.ac.cn
En
